A new clinical trial demonstrated positive effects caused by the drug combination lapatinib and trastuzumab against HER2 positive breast cancer in a treatment period of just 11 days.
Led by researchers at the Institute of Cancer Research, London, the University of Manchester, and University Hospital of South Manchester, the study comprised 257 women with HER2 positive breast cancer who were split into groups and treated for 11 days prior to surgery. Women who were treated with the drug combination were compared to women who received only one the drugs or no drugs before undergoing surgery. To assess results, samples of the tumor tissue were taken from an initial biopsy and once again during surgery, to determine if there was a drop in Ki67 protein, which indicates cell proliferation.

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